In the second part of 12 Rounds, Nick Malloy – a medical technician – witnesses a horrible traffic accident. The car is blew up ripping the night and he rushed to rescue the victims sticking in the flame. But thing that he did not expect is that he is the peson who is targetted. Nick is swirled into the cat nad mouse game with these gangsters while his wife is abducted. EMT and policemen try to find the reason why Nick is chosen in the gangster’s game. Could Nick rescue his wife?